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Publications / Oral presentations


Maares, M.; Keil, C.; Löher, L.; Weber, A.; Andorfer-Sarr, A.; Haase, H.; Iturri, J.; Toca-Herrera, J.L. Time- and Zinc-Related Changes in Biomechanical Properties of Human Colorectal Cancer Cells Examined by Atomic Force Microscopy. Biology 20209, 468.

Keil, C.; Hübner, C.; Richter, C.; Lier, S.; Barthel, L.; Meyer, V.; Subrahmanyam, R.; Gurikov, P.; Smirnova, I.; Haase, H. Ca-Zn-Ag Alginate Aerogels for Wound Healing Applications: Swelling Behavior in Simulated Human Body Fluids and Effect on Macrophages. Polymers 202012, 2741.

Hanbing, Wu & Haase, Hajo & Mahltig, Boris. (2020). Cationic Pretreatment for Reactive Dyeing of Cotton and its Simultaneous Antibacterial Functionalisation. TEKSTILEC. 63. 27-37. 10.14502/Tekstilec2020.63.27-37.

Maares, Maria & Haase, Hajo. (2020). A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models. Nutrients. 12. 762. 10.3390/nu12030762.

Haase, Hajo & Ellinger, Sabine & Linseisen, Jakob & Neuhäuser-Berthold, Monika & Richter, Margrit. (2020). Revised D-A-CH-reference values for the intake of zinc. Journal of Trace Elements in Medicine and Biology. 61. 126536. 10.1016/j.jtemb.2020.126536.

Yücesan, Gündoğ & Zorlu, Yunus & Brown, Connor & Keil, C. & Ayhan, Mehmet & Haase, Hajo & Thompson, Richard & Lengyel, Imre. (2020). Fluorescent arylphosphonic acids: synergic interactions between bone and fluorescent core. Chemistry - A European Journal. 10.1002/chem.202001613.

Lossow, Kristina & Kopp, Johannes & Schwarz, Maria & Finke, Hannah & Winkelbeiner, Nicola & Renko, Kostja & Meçi, Xheni & Ott, Christiane & Alker, Wiebke & Hackler, Julian & Grune, Tilman & Schomburg, Lutz & Haase, Hajo & Schwerdtle, Tanja & Kipp, Anna. (2020). Aging affects sex- and organ-specific trace element profiles in mice. Aging. 12. 10.18632/aging.103572.

Maares, Maria & Keil, C. & Straubing, Sophia & Robbe-Masselot, Catherine & Haase, Hajo. (2020). Zinc Deficiency Disturbs Mucin Expression, O-Glycosylation and Secretion by Intestinal Goblet Cells. International Journal of Molecular Sciences. 21. 6149. 10.3390/ijms21176149.

Alker, Wiebke & Haase, Hajo. (2020). Comparison of Free Zinc Levels Determined by Fluorescent Probes in THP1 Cells Using Microplate Reader and Flow Cytometer. Biological Trace Element Research. 10.1007/s12011-020-02355-w.

Ludszuweit, Marie & Schmacht, Maximilian & Keil, C. & Haase, Hajo & Senz, Martin. (2020). Impact of Media Heat Treatment on Cell Morphology and Stability of L. acidophilus, L. johnsonii and L. delbrueckii subsp. delbrueckii during Fermentation and Processing. Fermentation. 6. 94. 10.3390/fermentation6040094.

Keil, C., Maares, M., Kröncke, N. et al. Dietary zinc enrichment reduces the cadmium burden of mealworm beetle (Tenebrio molitor) larvae. Sci Rep 10, 20033 (2020).


Haase, Hajo & Schomburg, Lutz. (2019). You’d Better Zinc—Trace Element Homeostasis in Infection and Inflammation. Nutrients. 11. 2078. 10.3390/nu11092078.

Alker, Wiebke & Schwerdtle, Tanja & , Schomburg & Haase, Hajo. (2019). A Zinpyr-1-based Fluorimetric Microassay for Free Zinc in Human Serum. International Journal of Molecular Sciences. 20. 4006. 10.3390/ijms20164006.

Subrahmanyam, Raman & Keil, C & Dieringer, Paul & Hübner, Christopher & Bueno Morales, Alberto & Gurikov, Pavel & Nissen, Jörg & Holtkamp, Michael & Karst, Uwe & Haase, Hajo & Smirnova, Irina. (2019). Alginate aerogels carrying calcium, zinc and silver cations for wound care: Fabrication and metal detection. The Journal of Supercritical Fluids. 104545. 10.1016/j.supflu.2019.104545.

Maares, Maria & Ayhan, Mehmet & B. Yu, Kai & Ozgur Yazaydin, A & Harmandar, Kevser & Haase, Hajo & Beckmann, Jens & Zorlu, Yunus & Yücesan, Gündoğ. (2019). Alkali Phosphonate Metal‐Organic Frameworks. Chemistry. 10.1002/chem.201902925.

Chen, Gaoshi & Haase, Hajo & Mahltig, Boris. (2019). Chitosan-modified silica sol applications for the treatment of textile fabrics: a view on hydrophilic, antistatic and antimicrobial properties. Journal of Sol-Gel Science and Technology. 10.1007/s10971-019-05046-8.

Yücesan, Gündoğ & Maares, Maria & Ayhan, Mehmet & B. Yu, Kai & Ozgur Yazaydin, A & Harmandar, Kevser & Haase, Hajo & Beckmann, Jens & Zorlu, Yunus. (2019). Alkali‐phosphonate‐MOFs. Chemistry. 10.1002/chem.201902207.

Baesler, Jessica & Kopp, Johannes & Pohl, Gabriele & Aschner, Michael & Haase, Hajo & Schwerdtle, Tanja & Bornhorst, Julia. (2019). Zn homeostasis in genetic models of Parkinson’s disease in Caenorhabditis elegans. Journal of Trace Elements in Medicine and Biology. 10.1016/j.jtemb.2019.05.005.

Kröncke, Nina & Grebenteuch, Sandra & Keil, C & Demtroeder, Sebastian & Kroh, Lothar & Thünemann, Andreas & Benning, Rainer & Haase, Hajo. (2019). Effect of Different Drying Methods on Nutrient Quality of the Yellow Mealworm (Tenebrio molitor L.). Insects. 10. 10.3390/insects10040084.

Senz, Martin & Keil, C & Schmacht, Maximilian & Palinski, Sophie & Cämmerer, Bettina & Hageböck, Martin. (2019). Influence of Media Heat Sterilization Process on Growth Performance of Representative Strains of the Genus Lactobacillus. Fermentation. 5. 20. 10.3390/fermentation5010020.

Strmiska, Vladislav & Michalek, Petr & Lacková, Zuzana & Guráň, Roman & Krizkova, Sona & Vaníčková, Lucie & Zitka, Ondrej & Stiborová, Marie & Eckschlager, Tomas & Klejdus, Borivoj & Pacik, Dalibor & Tvrdikova, Eliska & Keil, C & Haase, Hajo & Adam, Vojtech & Heger, Zbynek. (2019). Sarcosine is a prostate epigenetic modifier that elicits aberrant methylation patterns through the SAMe‐Dnmts axis. Molecular Oncology. 13. 10.1002/1878-0261.12439. 



Charlyn Greiler, Lena & Haase, Hajo & Mahltig, Boris. (2018). Microwave Assisted Conversion of an Amino Acid into a Fluorescent Solution. Acta Chimica Slovenica. 65. 865-874. 10.17344/acsi.2018.4513.

Keller, Julia & Moldenhauer, Daniel & Byrne, Liam & Haase, Hajo & Resch-Genger, Ute & Koch, Matthias. (2018). Complexes of the Mycotoxins Citrinin and Ochratoxin A with Aluminum Ions and their Spectroscopic Properties. Toxins. 10. 538. 10.3390/toxins10120538.

Sumarokova, Maria & Iturri, Jagoba & Weber, Andreas & Maares, Maria & Keil, C & Haase, Hajo & Toca-Herrera, Jose Luis. (2018). Influencing the adhesion properties and wettability of mucin protein films by variation of the environmental pH. Scientific Reports. 8. 10.1038/s41598-018-28047-z.

Keller, Julia & Hantschke, Luisa & Haase, Hajo & Koch, Matthias. (2018). Synthesis and Structural Identification of a Biaryl Ether-Linked Zearalenone Dimer. Molecules. 23. 2624. 10.3390/molecules23102624.

Maares, Maria & Keil, C & Koza, Jenny & Straubing, Sophia & Schwerdtle, Tanja & Haase, Hajo. (2018). In Vitro Studies on Zinc Binding and Buffering by Intestinal Mucins. International Journal of Molecular Sciences. 19. 2662. 10.3390/ijms19092662.

Alker, Wiebke & Haase, Hajo. (2018). Zinc and Sepsis. Nutrients. 10. 976. 10.3390/nu10080976.

Keller, Julia & Borzekowski, Antje & Haase, Hajo & Menzel, Ralph & Ruess, Liliane & Koch, Matthias. (2018). Toxicity Assay for Citrinin, Zearalenone and Zearalenone-14-Sulfate Using the Nematode Caenorhabditis elegans as Model Organism. Toxins. 10. 284. 10.3390/toxins10070284.

Mahltig, B & Grethe, T & Haase, Hajo. (2018). Antimicrobial coatings obtained by sol-gel method. 10.1007/978-3-319-32101-1_102.

Maares, Maria & Duman, Ayse & Keil, C & Schwerdtle, Tanja & Haase, Hajo. (2018). The impact of apical and basolateral albumin on intestinal zinc resorption in the Caco-2/HT-29-MTX co-culture model. Metallomics. 10. 10.1039/C8MT00064F.

Mahltig, Boris & Charlyn Greiler, Lena & Klöcker, Michaela & Ehrmann, Andrea & Haase, Hajo. (2018). Mikrowellensynthese zur Realisierung von fluoreszierenden Ausrüstungsmitteln. Melliand Textilberichte. 99.

Haase, Hajo. (2018). Innate Immune Cells Speak Manganese. Immunity. 48. 616-618. 10.1016/j.immuni.2018.03.031.

Bulut, Aysun & Maares, Maria & Atak, Kaan & Zorlu, Yunus & Çoşut, Bünyemin & Zubieta, Jon & Beckmann, Jens & Haase, Hajo & Yücesan, Gündoğ. (2018). Synthesis of Molecular Metal Organophosphonate Cages and Macrocycles.

Bulut, Aysun & Maares, Maria & Atak, Kaan & Zorlu, Yunus & Çoşut, Bünyemin & Zubieta, Jon & Beckmann, Jens & Haase, Hajo & Yücesan, Gündoğ. (2018). Mimicking cellular phospholipid bilayer packing creates predictable crystalline molecular metal–organophosphonate macrocycles and cages. CrystEngComm. 20. -. 10.1039/C8CE00072G.

Maares, Maria & Keil, C & Thomsen, Susanne & Günzel, Dorothee & Wiesner, Burkhard & Haase, Hajo. (2018). Characterization of Caco-2 cells stably expressing the protein-based zinc probe eCalwy-5 as a model system for investigating intestinal zinc transport. Journal of Trace Elements in Medicine and Biology. 49. 10.1016/j.jtemb.2018.01.004.

Trame, Sarah & Wessels, Inga & Haase, Hajo & Rink, Lothar. (2018). A Short 18 Items Food Frequency Questionnaire Biochemically Validated to Estimate Zinc Status in Humans. Journal of Trace Elements in Medicine and Biology. 49. 10.1016/j.jtemb.2018.02.020.

Senz, Martin & Keil, C & Schmacht, Maximilian & Palinski, Sophie & Cämmerer, Bettina & Hageböck, Martin. (2019). Influence of Media Heat Sterilization Process on Growth Performance of Representative Strains of the Genus Lactobacillus. Fermentation. 5. 20. 10.3390/fermentation5010020.

Grethe T, Mahltig, B, Miao H, Kick T, Haase Hajo, Kopietz, M, Grishchuk S (2018) Fibers for Fully Bio-Based Fiber Reinforced Materials. In: Y. Kyosev et al. (Ed.): Narrow and Smart Textiles, Springer International Publishing, 33-48. ISBN 978-3-319-69049-0


Madeleine Thyssen, Georgina & Keil, C & Wolff, Melanie & Sperling, Michael & Kadow, Daniel & Haase, Hajo & Karst, Uwe. (2017). Bioimaging of the elemental distribution in cocoa beans by means of LA-ICP-TQMS. Journal of Analytical Atomic Spectrometry. 33. 10.1039/C7JA00354D.

Bornhorst J, Kipp AP, Haase H, Meyer S, Schwerdtle T (2017) The crux of inept biomarkers for risks and benefits of trace elements. Trends Anal Chem doi: 10.1016/j.trac.2017.11.007

Haase H, Jordan L, Keitel L, Keil C, Mahltig B (2017) Comparison of methods for determining the effectiveness of antibacterial functionalized textiles. PLoS ONE12(11): e0188304. doi: 10.1371/journal.pone.0188304

Reiber C, Brieger A, Engelhardt G, Hebel S, Rink L, Haase H (2017) Zinc chelation decreases IFN-β-induced STAT1 upregulation and iNOS expression in RAW 264.7 macrophages. J Trace Elem Med Biol. 44:76-82. doi:10.1016/j.jtemb.2017.05.011.

Keller J, Haase H, Koch M (2017) Hydroxylation and dimerization of zearalenone: comparison of chemical, enzymatic and electrochemical oxidation methods. World Mycotoxin Journal, doi:10.3920/WMJ2017.2213

Hoeger J, Simon TP, Beeker T, Marx G, Haase H, Schuerholz T. (2017) Persistent low serum zinc is associated with recurrent sepsis in critically ill patients – A pilot study. PLoS One 12(5): e0176069. doi:10.1371/journal.pone.0176069. 

Bulut A, Wörle M, Zorlu Y, Kirpi E, Kurt H, Zubieta J, Grabowsky S, Beckmann J, Yücesan G. (2017) A potential Cu/V-organophosphonate platform for tailored void spaces via terpyridine mold casting. Acta Crystallogr B Struct Sci Cryst Eng Mater. 73(Pt 2):296-303. doi:10.1107/S2052520617000245

Schütrumpf A, Bulut A, Hermer N, Zorlu Y, Kirpi E, Stock N, Yazaydin Ö, Yücesan G, Beckmann J. (2017) From Tetrahedral Tetraphosphonic Acids E[p-C6H4P(O)(OH)2]4 (E=C, Si) to Porous Cu- and Zn-MOFs with Large Surface Areas. Chemistry select 2(10): 3035-3038. doi: 10.1002/slct.201700573

Keller J, Haase H, Koch M. (2017) Electrochemical simulation of biotransformation reactions of citrinin and dihydroergocristine compared to UV irradiation and Fenton-like reaction. Anal Bioanal Chem. doi: 10.1007/s00216-017-0350-6. 

Anyz J, Vyslouzilova L, Vaculovic T, Tvrdonova M, Kanicky V, Haase H, Horak V, Stepankova O, Heger Z, Adam V. (2017) Spatial mapping of metals in tissue-sections using combination of mass-spectrometry and histology through image registration. Sci Rep. 7:40169. doi: 10.1038/srep40169 


Hasan R, Rink L, Haase H (2016) Chelation of Free Zn2+ Impairs Chemotaxis, Phagocytosis, Oxidative Burst, Degranulation, and Cytokine Production by Neutrophil Granulocytes. Biol. Trace Elem. Res. 171(1): 79-88. doi: 10.1007/s12011-015-0515-0

Haase H, Fahlenkamp A, Schettgen T, Esser A, Gube M, Ziegler P, Kraus T, Rink L (2016) Immunotoxicity Monitoring in a Population Exposed to Polychlorinated Biphenyls. Int. J. Environ. Res. Public Health. 13(3): E295. doi:10.3390/ijerph13030295

Dörpinghaus M, Brieger A, Panichkina O, Rink L, Haase H. (2016) Lead ions abrogate lipopolysaccharide-induced nitric monoxide toxicity by reducing the expression of STAT1 and iNOS. J Trace Elem Med Biol. 37: 117-24. doi: 10.1016/j.jtemb.2016.04.009.

Haase H, Hebel S, Engelhardt G, Rink L (2016) Ethylmercury and Hg(2+) induce the formation of neutrophil extracellular traps (NETs) by human neutrophil granulocytes. Arch. Toxicol. 90(3): 543-50. doi: 10.1007/s00204-015-1484-y

Maares M, Haase H (2016) Zinc and immunity: An essential interrelation. Arch. Biochem. Biophys. 611: 58-65. doi: 10.1016/j.abb.2016.03.022.

Ollig J, Kloubert V, Weßels I, Haase H, Rink L (2016) Parameters Influencing Zinc in Experimental Systems in Vivo and in Vitro. Metals 6(3): 71. doi:10.3390/met6030071

Natarajan HS, Haase H, Mahltig B (2016) Polyvinylamine application for functionalization of polyethylene fiber materials. The Journal of The Textile Institute. doi: 10.1080/00405000.2016.1177246

Mahltig B, Zhang J, Wu L, Darko D, Wendt M, Lempa E, Rabe M, Haase H (2016) Effect pigments for textile coating: a review of the broad range of advantageous functionalization. J. Coat. Technol. Res. doi:10.1007/s11998-016-9854-9

Rosenkranz E, Metz CH, Maywald M, Hilgers RD, Weßels I, Senff T, Haase H, Jäger M, Ott M, Aspinall R, Plümäkers B, Rink L (2016) Zinc supplementation induces regulatory T cells by inhibition of Sirt-1 deacetylase in mixed lymphocyte cultures. Mol. Nutr. Food Res. 60(3): 661-71. doi: 10.1002/mnfr.201500524

Kessels JE, Wessels I, Haase H, Rink L, Uciechowski P (2016) Influence of DNA-methylation on zinc homeostasis in myeloid cells: Regulation of zinc transporters and zinc binding proteins. J. Trace Elem. Med. Biol. 37: 125-133. doi: 10.1016/j.jtemb.2016.02.003

Mahltig B, Grethe T, Haase H (2016) Antimicrobial Coatings Obtained by Sol–Gel Method. In: Handbook of Sol-Gel Science and Technology, S. 1-27, Springer.

Grethe T, Vorneweg C, Haase H, Mahltig B (2016) Chapter 4: Natural Antibacterials for Technical Applications. In: Antibacterials: Synthesis, Properties an Biological Activities. Nova Science Publishers, ISBN: 978-1-63485-793-2

Grethe T, Haase H, Mahltig B (2016) Natural Materials for Surface Modification of Cellulosic Narrow Woven Fabrics — Strides Towards Fully Bio-based Composites in: Y. Kyosev (Ed.): Recent Developments in Braiding and Narrow Weaving, Springer International Publishing, 149-154. ISBN 978-3-319-29931-0

Haase H (2016) Chapter 21. Zinc Signals and Immune Function. In: Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals, 1st Edition, Academic Press, p261-271. ISBN: 978-0-12802-168-2


Bidu J, Grethe T, Haase H, Mahltig B (2015) Chapter 13: Inorganic Nanosol Coatings for Antimicrobial Treatment of Textiles. In: Comprehensive Guide for Nanocoatings Technology. Ed. Aliofkhazraei M, Nova Science Publishers, New York, ISBN 978-1-63482-647-1

Grethe T, Haase H, Natarajan HS, Limandoko N, Mahltig B (2015) Coating Process for antimicrobial textile surfaces derived from a polyester dyeing process. J. Coat. Technol. Res., im Druck

Haase H, Hebel S, Engelhardt G, Rink L (2015) The biochemical effects of extracellular Zn(2+) and other metal ions are severely affected by their speciation in cell culture media. Metallomics 7(1), 102–111

Hoeger J, Simon T-P, Doemming S, Thiele C, Marx G, Schuerholz T, Haase H (2015) Alterations in zinc binding capacity, free zinc levels and total serum zinc in a porcine model of sepsis. BioMetals 2015 Aug;28(4):693-700. doi: 10.1007/s10534-015-9858-4

Martin L, Schmitz S, De Santis R, Doemming S, Haase H, Hoeger J, Heinbockel L, Brandenburg K, Marx G, Schuerholz T (2015) Peptide 19-2.5 inhibits heparan sulfate-triggered inflammation in murine cardiomyocytes stimulated with human sepsis serum. PLOS one 10(5):e0127584

Heiliger E, Osmanagic A, Haase H, Golenhofen N, Grabrucker AM, Weth A, Baumgartner W (2015) N-cadherin-mediated cell adhesion is regulated by extracellular Zn(2+). Metallomics 7(2), 355–362

Mahltig B, Darko D, Günther K, Haase H (2015) Copper Containing Coatings for Metallized Textile Fabrics. J Fashion Technol Textile Eng 3:1.

Haase H (2015) Zink und Immunsystem – Ein Element mit vielen Funktionen. Natw. Rundsch. 68(1), 15–19

Martin L, De Santis R, Koczera P, Simons N, Haase H, Heinbockel L, Brandenburg K, Marx G, Schuerholz T. (2015) The Synthetic Antimicrobial Peptide 19-2.5 Interacts with Heparanase and Heparan Sulfate in Murine and Human Sepsis. PLoS One. 10(11):e0143583.


Grethe T, Bidu J, Mahltig B, Haase H (2014) Antimicrobial finishing of textiles by modified clay minerals. Melliand International 20(3), 173–174

Mahltig B, Schulenberg D, Grethe T, Textor T, Gutmann JS, Haase H (2014) Biokomposit-basierte anorganische Ausrüstungsmittel zur effektiven antimikrobiellen Ausrüstung. TextilPlus 05/06-2014, 27–30

Grethe T, Bidu J, Mahltig B, Haase H (2014) Antimicrobial finishing of textiles by modified clay minerals. Technical Textiles 2/2014:E64–E66

Grethe T, Bidu J, Mahltig B, Haase H (2014) Antimikrobielle Ausrüstung von Textilien durch modifizierte Tonminerale. Melliand Textilberichte 57(1), 26–28

Fahlenkamp AV, Coburn M, Rossaint R, Stoppe C, Haase H (2014) Comparison of the effects of xenon and sevoflurane anaesthesia plus surgery on leukocyte function in a randomized controlled trial. Brit. J. Anaesthesiol. 112(2), 272–280

Haase H, Fahmi A, Mahltig B (2014) Impact of Silver Nanoparticles and Silver Ions on Innate Immune Cells. J. Biomed. Nanotechnol. 10: 1146–1156

Plum LM, Brieger A, Engelhardt G, Hebel S, Nessel A, Arlt M, Kaltenberg J, Schwaneberg U, Huber M, Rink L, Haase H (2014) PTEN-inhibition by zinc ions augments interleukin-2-mediated Akt phosphorylation. Metallomics 6(7), 1277–1287

Mayer LS, Uciechowski P, Meyer S, Schwerdtle T, Rink L, Haase H (2014) Differential impact of zinc deficiency on phagocytosis, oxidative burst, and production of pro-inflammatory cytokines by human monocytes. Metallomics 6(7), 1288–1295

Fahlenkamp AV, Coburn M, de Prada A, Gereitzig N, Beyer C, Haase H, Rossaint R, Gempt J, Ryang Y-M (2014) Expression analysis following argon treatment in an in vivo model of transient middle cerebral artery occlusion in rats. Med. Gas. Res. 4, 11

Topp K, Haase H, Degen C, Mahltig B (2014) Metallic effect pigments to realize antimicrobial and conductive coating of textiles. Zur Veröffentlichung angenommen bei Journal of Coatings Technology and Research 11(6), 943–957

Haase H, Rink L (2014) Zinc signals and immune function. Biofactors 40(1), 27–40

Haase H, Rink L (2014) The multiple impacts of zinc on immune function. Metallomics 6(7), 1175–1180


Mahltig B, Soltmann U, Haase H (2013) Modification of algae with zinc, copper and silver ions for usage as natural composite for antibacterial applications. Mat. Sci. Eng.C 33, 979–983

Mahltig B, Tatlises B, Fahmi A, Haase H (2013) Dendrimer stabilized silver particles for the antimicrobial finishing of textiles. Journal of the Textile Institute 104(10), 1042–1048

Jorissen A, Plum LM, Rink L, Haase H (2013) Impact of lead and mercuric ions on the interleukin-2-dependent proliferation and survival of T cells. Arch. Toxicol. 87(2), 249–258

Haase H, Hebel S, Engelhardt G, Rink L (2013) Application of Zinpyr-1 for the investigation of zinc signals in Escherichia coli. Biometals 26(1), 167–177

Hasan R, Rink L, Haase H (2013) Zinc signals in neutrophil granulocytes are required for the formation of neutrophil extracellular traps. Innate Immunity 19(3), 253–264

Brieger A, Rink L, Haase H (2013) Differential Regulation of TLR-Dependent MyD88 and TRIF Signaling Pathways by Free Zinc Ions. J. Immunol. 191(4), 1808–1817

Wessels I, Haase H, Engelhardt G, Rink L, Uciechowski P (2013) Zinc deficiency induces production of the proinflammatory cytokines IL-1β and TNFα in promyeloid cells via epigenetic and redox-dependent mechanisms. J. Nutr. Biochem. 24(1), 289–297

Gruber K, Maywald M, Rosenkranz E, Haase H, Plumäkers B, Rink L (2013) Zinc deficiency adversely influences interleukin-4 and interleukin-6 signaling. J. Biol. Regul. Homeost. Agents 27(3), 661–671

Mahltig B, Natarajan HS, El Brini O, Wissling P, Haase H (2013) Metallhaltige Beschichtungen auf Textil – Konzepte und Eigenschaften Textilplus 01/02-2013

Haase H, Rink L (2013) Zink und Immunsystem. Ernährung & Medizin, 28, 163–166

Haase H (2013) An element of life: competition for zinc in host-pathogen interaction. Immunity 39(4), 623–624

Haase H, Rink L (2013) Zinc and Immunity. Seiten 2375-2380. In: Encyclopedia of Metalloproteins. Eds. Uversky V, Kretsinger RH, Permyakov EA, Springer, New York, ISBN 978-1-4614-1532-9

bis 2012

Hönscheid A, Dubben S, Rink L, Haase H (2012) Zinc differentially activates mitogen-activated protein kinases in human T-cells. J. Nutr. Biochem., 23(1), 18–26

Haase H, Hieke N, Plum LM, Gruhlke MCH, Slusarenko AJ, Rink L (2012) Impact of Allicin on Macrophage Activity. Food Chem., 134(1), 141–148

Mahltig B, Haase H (2012) Comparison of the effectiveness of different silver-containing textile products on bacteria and human cells. Journal of the Textile Institute 103(11), 1262–1266

Fahlenkamp AV, Rossaint R, Haase H, Al Kassam H, Ryang YM, Beyer C,
Coburn M (2012) The noble gas argon modifies extracellular signal-regulated
kinase 1/2 signaling in neurons and glial cells. Eur. J. Pharmacol. 674 (2–3), 104–111

Mahltig B, Cheval N, Astachov V, Malkoch M, Haase H, Fahmi A (2012) 2,5 Hydroxyl dendrimers as stabilizing agent for preparation of colloidal silver particles – a study in respect to antimicrobial properties and toxicity against human cells. Colloid Polym. Sci. 290:1413–1421

Haase H, Engelhardt G, Hebel S, Rink L (2011) Mercuric ions inhibit mitogen-activated protein kinase dephosphorylation by inducing reactive oxygen species. Toxicol. Appl. Pharmacol. 250(1), 78–86

Brieger A, Bienefeld N, Hasan R, Goerlich R, Haase H (2011) Impact of perfluorooctanesulfonate and perfluorooctanoic acid on human peripheral leukocytes. Toxicol. in Vitro. 25(4), 960–968

Mahltig B, Reibold M, Gutmann E, Textor T, Gutmann J, Haufe H, Haase H (2011) Preparation of Silver Nanoparticles Suitable for Textile Finishing Processes to Produce Textiles with Strong Antibacterial Properties against Different Bacteria Types. Z. Naturforsch. B (9), 905–916

Uciechowski P, Imhoff H, Lange C, Meyer CG, Browne EN, Kirsten DK, Schröder AK, Schaaf B, Al-Lahham A, Reinert RR, Reiling N, Haase H, Hatzmann A, Fleischer D, Heussen N, Kleines M, Rink L (2011) Susceptibility to tuberculosis is associated with TLR1 polymorphisms resulting in a lack of TLR1 cell surface expression. J. Leukoc. Biol. 90(2), 377–388

Rink L, Kruse A, Haase H (2011) Immunologie für Einsteiger. Spektrum Akademischer Verlag, 1. Auflage (2011), ISBN: 978-3-8274-2439-9, 2., neu bearbeitete und aktualisierte Auflage (2015), ISBN 978-3-6624-4842-4

Haase H (2011) Zinc homeostasis and the immune system. In: Mikronährstoffe: Nahrungsergänzungsmittel, Analytik, Essentialität und Toxizität, Ed. Schwerdtle T, Ebert F, Hartwig A, Herbert Utz Verlag, München, ISBN: 978-3-8316-4053-9

Haase H, Rink L (2011) Zinc signalling. In: Zinc in human health. Ed. L. Rink. IOS Press, Amsterdam

Dubben S, Hönscheid A, Winkler K, Rink L, Haase H (2010) Cellular zinc homeostasis is a regulator in monocyte differentiation of HL-60 cells by 1{alpha},25-dihydroxyvitamin D3. J. Leukoc. Biol. 87(5), 833–844

Kaltenberg J, Plum LM, Ober-Blöbaum JL, Hönscheid A, Rink L, Haase H (2010) Zinc Signals Promote IL-2-Dependent Proliferation of T Cells. Eur. J. Immunol. 40(5), 1496–1503

Haase H, Ober-Blöbaum JL, Hebel S, Engelhardt G, Rink L (2010) Cadmium ions inhibit MAPK dephosphorylation and trigger monocytic production of TNF-alpha by MAPK activation. Toxicol. Lett. 198(2), 152–158

Ober-Blöbaum JL, Hebel S, Engelhardt G, Rink L, Haase H (2010) Cadmium Ions Promote Monocytic Differentiation of Human Leukemia HL-60 Cells treated with 1alpha,25-Dihydroxyvitamin D3. Biol. Chem. 391(11), 1295–1303

Fahlenkamp AV, Coburn M, Haase H, Kipp M, Ryang YM, Rossaint R, Beyer C (2010) Xenon enhances LPS-induced IL-1ß production in microglia via the extracellular signal-regulated kinase 1/2 pathway. J. Mol. Neurosci. (45(1), 48–59

Haase H, Rink L (2010) Das essentielle Spurenelement Zink. Biologie in unserer Zeit 40, 314

Plum LM, Rink L, Haase H (2010) The essential toxin: impact of zinc on human health. International Journal of Environmental Research and Public Health 7(4), 1342–1365

Haase H, Hebel S, Engelhardt G, Rink L (2009) Zinc ions cause the thimerosal-induced signal of fluorescent calcium probes in lymphocytes. Cell Calcium 45(2), 185–191

Wellenreuther G, Cianci M, Tucoulou R, Meyer-Klaucke W, Haase H (2009) Zinc-rich macrophage vesicles store the metal in a complexed form. Biochem. Biophys. Res. Comm. 308, 198–203

Haase H, Rink L (2009) The immune system and the impact of zinc during aging. Immunity & Ageing 6, 9

Hönscheid A, Rink L, Haase H (2009) T-lymphocytes: a target for stimulatory and inhibitory effects of zinc ions. Endocrine, Metabolic and Immune disorders – Drug Targets 9(2), 132–134

Haase H, Rink L (2009) Functional Significance of zinc-related signalling pathways in immune cells. Annu. Rev. Nutr. 29, 133–152

Haase H, Maret W (2009) Chapter 8: The regular and signaling functions of zinc in human cellular physiology. In: Cellular and molecular biology of metals. Ed: Koropatnik J, Zalups RK, Taylor and Francis. ISBN: 978-1-42005-997-7

Haase H, Rink L (2009) Immunotoxicology of Cadmium. In: Cadmium in the Environment, Ed.: Columbus F, Novapublishers, New York, ISBN: 978-1-60741-934-1

Haase H, Ober-Blöbaum JL, Engelhardt G, Hebel S, Heit A, Heine H, Rink L (2008) Zinc signals are essential for lipopolysaccharide-induced signal transduction in monocytes. J. Immunol. 181, 6491–6502

Haase H, Maret W (2008) Partial oxidation and oxidative polymerization of metallothionein. Electrophoresis 29(20), 4169–4176

Mazzatti DJ, Uciechowski P, Hebel S, Engelhardt G, White AJ, Powell JR, Rink L, Haase H (2008) Effects of long-term zinc supplementation and deprivation on gene expression in human THP-1 mononuclear cells. J. Trace Elem. Med. Biol. 22(4), 325–336

Overbeck S, Rink L, Haase H (2008) Modulating the immune response by oral zinc supplementation: A single approach for multiple diseases. Archivum Immunologiae et Therapiae Experimentalis. 56(1), 15–30

Haase H, Overbeck S, Rink L (2008) Zinc supplementation for the treatment or prevention of disease: Current status and future perspectives. Exp. Gerontol. 43(5), 394–408

Haase H, Rink L (2008) Zinc and the altered immune system in the elderly. In: Immunosenescence, Ed.: Pawelec G, Landes Bioscience. ISBN: 978-0-387-76840-3

Haase H, Mazzatti DJ, White A, Ibs KH, Engelhardt G, Hebel S, Powell JR, Rink L (2007) Differential gene expression after zinc supplementation and deprivation in human leukocyte subsets. Mol. Med. 13, 362–370

von Bülow V, Dubben S, Engelhardt G, Hebel S, Plümäkers B, Heine H, Rink L, Haase H (2007) Zinc-dependent suppression of TNF-α production is mediated by protein kinase A-induced inhibition of Raf-1, IKKβ, and NF-κB. J. Immunol. 179, 4180–4186

Rink L, Haase H (2007) Zinc homeostasis and immunity. Trends Immunol. 28(1), 1–4

Haase H, Rink L (2007) Role of zinc in the signal transduction of monocytes. Biometals 20(3-4), 579-585

Haase H, Hebel S, Engelhardt G, Rink L (2006) Flow cytometric measurement of labile zinc in peripheral blood mononuclear cells. Anal. Biochem. 352, 222–230

Haase H, Rink L (2006) Influence of zinc on immune function. Mol. Asp. Immunobiol. 18, 2

Haase H, Rink L (2006) Correlation between zinc status and immune function in the elderly. Biogerontology 7(5–6), 421–428

Haase H, Rink L (2006) The physiological role of zinc ions in mammalian signal transduction. In: Focus on signal transduction research, Ed.: G. MacAlpine, Novapublishers, New York, ISBN: 1-60021-376-6

Haase H, Maret W (2005) Fluctuations of cellular, available zinc modulate insulin signaling via inhibition of protein tyrosine phosphatases. J. Trace Elem. Biol. Med. 19, 37–42

von Bülow V, Rink L, Haase H (2005) Zinc-mediated inhibition of cyclic nucleotide phosphodiesterase activity and expression suppresses TNF-α and IL-1β production in monocytes by elevation of cGMP. J. Immunol. 175, 4697–4705

Haase H, Maret W (2005) Protein tyrosine phosphatases as targets of the combined insulinomimetic effects of zinc and oxidants. Biometals 18, 333–338

Haase H, Maret W (2005) Störung des Zinkstoffwechsels bei Diabetes Mellitus. Ernährung und Medizin 20, 126–132

Haase H, Maret W (2004) A differential assay for the reduced and oxidized states of metallothionein and thionein. Anal. Biochem. 333, 19–26

Haase H, Maret W (2003) Intracellular zinc fluctuations modulate protein tyrosine phosphatase activity in insulin/insulin-like growth factor-1 signaling. Exp. Cell Res. 291, 289–298

Haase H, Beyersmann D (2002) Intracellular zinc distribution and transport in C6 rat glioma cells. Biochem. Biophys. Res. Comm. 296, 923–928

Wätjen W, Haase H, Biagioli M, Beyersmann D.(2002) Induction of apoptosis in mammalian cells by cadmium and zinc. Environ. Health Perspect. 110 suppl. 5, 865–867

Haase H, Wätjen W, Beyersmann D (2001) Zinc induces apoptosis that can be suppressed by lanthanum in C6 rat glioma cells. Biol. Chem. 382, 1227–1234

Wätjen W, Benters J, Haase H, Schwede F, Jastorff B, Beyersmann D (2001) Zn2+ and Cd2+ increase the cyclic GMP level in PC 12 cells by inhibition of the cyclic nucleotide phosphodiesterase. Toxicology 157, 167–175

Kröncke KD, Haase H, Beyersmann D, Kolb-Bachofen V, Hayer-Hartl M (2001) Nitric oxide inhibits the cochaperone activity of the RING finger like protein DnaJ. NO Biol. Chem. 5, 289–295

Haase H (2001) Zinkhomöostase in Säugerzellen: Untersuchungen zur Aufnahme, intrazellulären Verteilung und Toxizität. GCA-Verlag, ISBN 978-3-8986-3024-2

Beyersmann D, Haase H (2001) Functions of zinc in signaling, proliferation and differentiation of mammalian cells. Biometals, 14, 331–341

Beyersmann D, Haase H (2001) Functions of zinc in signaling, proliferation and differentiation of mammalian cells. In: Zinc Biochemistry, Physiology, and Homeostasis. Recent Insides and Current Trends. Ed.: W. Maret. Kluwer Academic Publishers, ISBN 1-4020-0217-3, 145–155

Haase H, Beyersmann D (1999) Uptake and intracellular distribution of labile and total Zn(II) in C6 rat glioma cells investigated with fluorescent probes and atomic absorption. Biometals 12, 247–254

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Oral presentations


Juni, ISZB Meeting, Pyla/Zypern “Total and free serum zinc levels during sepsis”

September, 33. Joint Annual Meeting of the German Society for Minerals and Trace Elements (GMS) with Zinc-UK, Aachen “Investigation of zinc uptake and bioavailability in an in vitro model of the gastrointestinal tract” 


März, 53. Wissenschaftlicher Kongress der DGE, Fulda “Das essenzielle Spurenelement Zink in der Immunreaktion“

April, IFU Technical Workshop, Berlin “Every medal has two sides: Essential and toxic effects of metals”


Juni, Zinc-Net training school on Metallothionein and its relation to zinc(II)ions, Brno/Tschechische Republik: „Zinc signals and the control of immune cell functions”

November, VIII International Society for Immunonutrition Conferene, Rio de Janeiro/Brasilien: „Interdependence of zinc status and immunity”


Juni, 15th Symposium on Trace Elements in Man and Animals (TEMA15), Orlando (FL)/USA: „Zinc regulation of cell signaling pathways”

Januar/Februar, Fünf Weiterbildungsveranstaltungen für PTA in Halle (Saale), Kassel, Kiel, Regensburg und Stuttgart „Immunbiologie der Halsschmerzen“


Januar, Forschungsretreat der Klinik für Operative Intensivmedizin, Aachen: „Zink und Entzündung“

April, Festkolloquium „Analytik“ der GDCh, Duisburg-Essen: „Zink und Gesundheit“

Juli, 8th Zinc-UK Meeting, Aberdeen/Großbritannien: „Application of low molecular weight fluorescent probes for incestigating a potential signaling function of free Zn2+ in bacteria“


Januar,International Society of Zinc Biology 2012 Conference, Melbourne/Australien: „Role of zinc signals in the IL-2 dependent proliferation of T-cells“

Juli, 4th Zinc-UK meeting, Cardiff/Großbritannien: „Zinc signals regulate IL-2-mediated Akt activation by inhibiting PTEN”


Februar, 3rd Zinc-UK meeting, London/Großbritannien: „Zinc signals in the immune response”

Mai, 4. Hohenheimer Ernährungsinformation, Hohenheim: „Think zinc: 50 Jahre Zink als essentielles Spurenelement”


September, International Symposium Signal Transduction and Disease, Aachen: „Monocyte activation by Toll-like receptor 4 depends on zinc signals”

Oktober, 19th International Congress of Nutrition, Bangkok/Thailand: „Zinc and signaling pathways in immune cells”

Dezember, ISZB Meeting, Jerusalem/Israel: „Zinc signals in the immune response”


Februar, Society for zinc biology meeting, Banff/Kanada: „Zinc signals regulate Immune cell function”

November, 24th annual meeting of the GMS (Society for Minerals and Trace Elements), Berlin: „Zinc homeostasis and immunity”

September, International Zinc Symposium, Darmstadt: „Zinkstatus und Sepsis: Balance zwischen antiinflammatorischer Wirkung und Immunsuppression“


Juni, ZincSignals 2007, Houston (TX)/USA: „Zinc and the signal transduction of immune cells”

September, Annual Meeting of the DGfI, Heidelberg: „Zinc ions act as a signal in leukocyte activation”


März, Ben Gurion University of the Negev, Beer-Sheva/Israel: „Role of zinc in the signal transduction of monocytes”

Juli, University of Texas Medical Branch, Galveston (TX)/USA: „Zinc: a signaling ion in immunology”

August, 5th International BioMetals Symposium, Welches (OR)/USA: „Signal transduction in monocytes: the role of zinc ions”

September, ZincSignals 2006, Monte Oliveto/Italien: „Effect of zinc on intracellular signal transduction and cytokine secretion of monocytes“


Mai, FESTEM-Meeting, München: „Intracellular zinc fluctuations modulate protein tyrosine phosphatase activity in insulin/insulin-like growth factor-1 signaling“

Juni, Zinc Signals 2004 Conference, Aarhus/Dänemark: „Intracellular zinc: Regulation of protein tyrosine phosphatase activity in insulin and IGF-1 signaling“

September, International Biometals Symposium 2004, Garmisch-Partenkirchen: „Fluctuations of intracellular zinc regulate insulin/IGF-1 signaling“

Oktober, Joint Meeting of the Dutch and German Societies for Immunology, Maastricht/Niederlande: „LPS-induced release of intracellular zinc triggers TNF-alpha synthesis in human monocytes“


Oktober, Molekularbiologisches Kolloquium, Center for Biomolecular Interactions Bremen: „Zinc as a physiological regulator of insulin/IGF-1 signals“


Januar, Zentrum für Umweltforschung und Technologie (UFT), Bremen: „Ist intrazelluläres Zink ein ‚Master-Hormon‘ für Proliferation, Differenzierung und Apoptose?“


Dezember, Jungchemikerforum der GDCh, Bremen: „Zinkhomöostase in Säugerzellen: Untersuchungen zur Aufnahme, intrazellulären Verteilung und Toxizität“

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